Endocrine Abstracts

Introduction: Mesenchymal bone marrow cells (BMCs) contain pluripotent progenitor cells, which differentiate into multiple lineages. In a previous study, we reported that adenovirus-mediated forced expression of steroidogenic factor-1/adrenal 4 binding protein (SF-1/Ad4BP), an essential nuclear receptor for steroidogenesis, could transform human BMCs into steroidogenic cells, suggesting a possibility of cell transplantation therapy in patients with steroid deficiency. In this ...

Androgen is an important factor for determining body composition in males. Abdominal obesity is inversely correlated with serum androgen levels in men. Androgen receptor (AR) null male mice revealed late-onset visceral obesity, accompanying energy balance abnormality. We previously reported a novel synthetic steroid, S42 as a promising candidate of a selective androgen receptor modulator (SARM). When orchiectomized Sprague-Dawley rats were administered with S42 for 3 weeks, th...

Introduction: Optimal glucocorticoid (GC) replacement in patients with adrenal insufficiency (AI) is desirable for the prevention of long-term side effects of GC. Both hyperglycemia and hypoglycemia are the risk of atherosclerosis. For the determination of optimal GC replacement method in patients with AI, we tested a utility of continuous glucose monitoring (CGM).Subjects and methods: Three patients with primary or secondary AI were examined. Case 1, 50...